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Browser File Handling

Office 365 Browser File Handling 
 In my testing, IE8 will automatically open PDFs in Adobe Reader after saving locally if you make these changes:
(assuming your SharePoint Online site is added to your trusted sites in IE. This behavior is more like how Firefox browser handles the 'no-open' header)
 
 
 
 
To see how to open PDFs from o365 directly in the browser click here: